Resources
Practical implementation guidance for drug interaction APIs, source-data strategy, and terminology normalization.
A developer-focused comparison of Wolters Kluwer Medi-Span and RxLabelGuard for drug interaction checking. Covers data sources, API access models, pricing, severity scoring, and integration complexity to help you choose the right tool.
A comprehensive guide to drug interaction severity classifications used in clinical decision support systems. Covers the five severity tiers from minor to contraindicated, with clinical examples, scoring methodology, and how RxLabelGuard assigns severity from FDA label text.
A timeline of free drug interaction API shutdowns from 2024 to 2026, including NLM's RxNav Interaction API discontinuation and DrugBank's checker retirement. Covers what remains available, the openFDA raw data path, and how RxLabelGuard fills the gap with a free tier.
A step-by-step developer tutorial for using the NLM RxNorm API to resolve drug names to RxCUI identifiers. Covers exact match, normalized match, and fuzzy approximate matching with curl examples and JavaScript code. Explains how RxLabelGuard uses RxNorm internally for reliable drug resolution.
A developer implementation guide for building drug interaction alerts using CDS Hooks and FHIR. Covers the CDS Hooks specification, order-sign and order-select hook points, the HL7 PDDI-CDS Implementation Guide, and how to use RxLabelGuard as the backend knowledge service for CDS Hook responses.
A developer guide to extracting drug interaction data from FDA Structured Product Labeling. Covers the SPL format, querying openFDA for label data, which label fields contain interaction information, parsing challenges with unstructured text, and how AI extraction turns label prose into structured interaction data.
Step-by-step tutorial for checking drug interactions via API. Complete code examples in cURL, Python, and JavaScript using RxLabelGuard's REST endpoints. Covers structured and natural language queries, response parsing, and production integration patterns.
We compared 5 drug interaction API prices side-by-side. See exactly what DrugBank, FDB, Micromedex, and RxLabelGuard cost -- from free tiers to enterprise. Save thousands.
Deep technical guide to the openFDA drug label API: endpoints, query syntax, rate limits, key fields for drug interaction work, caching strategies, practical examples, and common pitfalls. Covers how to go from raw FDA label text to structured interaction data.
A balanced decision guide for developers choosing between open/free public data sources like openFDA and RxNorm, managed APIs, and commercial drug interaction databases. Covers build vs buy trade-offs, hidden costs, and a comparison matrix.
A step-by-step tutorial for building a working drug interaction checker using the RxLabelGuard API. Includes complete Python and JavaScript code, example output, and guidance on extending to a web interface.
An examination of alert fatigue in clinical decision support systems, why it leads clinicians to override critical drug interaction warnings, and how five-level severity scoring with evidence citations helps build alerts that practitioners actually read.
DrugBank is retiring its free Drug-Drug Interaction Checker on March 25, 2026. A practical look at the timeline, public data alternatives, architecture patterns, and migration considerations for teams that need to replace this capability.
NLM discontinued the RxNav Drug Interaction API in January 2024. This guide covers what was removed, what RxNorm capabilities remain, and how to build a replacement interaction detection pipeline using public FDA data.
Where openFDA and DailyMed overlap, where they differ, and why most teams still build a normalization layer.
Why identifier normalization and label evidence should be treated as separate layers in medication safety APIs.